Donald M Bers Selected Research

Polymorphic catecholergic ventricular tachycardia

10/2021	Cardiomyocyte Na+ and Ca2+ mishandling drives vicious cycle involving CaMKII, ROS, and ryanodine receptors.
3/2014	Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants.
8/2008	Modulation of SR Ca release by luminal Ca and calsequestrin in cardiac myocytes: effects of CASQ2 mutations linked to sudden cardiac death.

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Donald M Bers Research Topics

Disease

65	Heart Failure 12/2022 - 01/2002
28	Cardiac Arrhythmias (Arrythmia) 12/2023 - 01/2002
14	Cardiomegaly (Heart Hypertrophy) 12/2022 - 05/2003
13	Hypertrophy 12/2022 - 05/2003
7	Heart Diseases (Heart Disease) 10/2021 - 01/2008
7	Ventricular Tachycardia 03/2016 - 01/2007
5	Hyperglycemia 12/2022 - 01/2020
5	Ischemia 01/2021 - 02/2006
4	Diabetic Cardiomyopathies 10/2021 - 02/2012
4	Atrial Fibrillation 01/2021 - 01/2017
4	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 07/2015 - 05/2003
4	Cardiac Sudden Death (Sudden Cardiac Arrest) 06/2015 - 08/2008
4	Infections 03/2009 - 12/2004
3	Type 2 Diabetes Mellitus (MODY) 12/2022 - 02/2012
3	Muscular Diseases (Myopathy) 01/2022 - 02/2006
3	Polymorphic catecholergic ventricular tachycardia 10/2021 - 08/2008
3	Reperfusion Injury 01/2020 - 02/2006
3	Inflammation (Inflammations) 01/2017 - 01/2015
3	Cardiomyopathies (Cardiomyopathy) 04/2015 - 10/2012
3	Sudden Death 03/2015 - 11/2002
3	Long QT Syndrome 03/2014 - 12/2007
2	Cardiovascular Diseases (Cardiovascular Disease) 12/2021 - 01/2019
2	Diabetes Mellitus 01/2020 - 10/2013
2	Prediabetic State (Prediabetes) 01/2020 - 02/2012
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2019 - 10/2012
2	Myocardial Infarction 01/2017 - 01/2014
2	Infarction (Infarctions) 01/2017 - 04/2007
2	Fibrosis (Cirrhosis) 08/2015 - 05/2005
2	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 04/2015 - 05/2005
2	Familial Hypertrophic Cardiomyopathy (Cardiomyopathy, Familial Hypertrophic) 01/2013 - 05/2005
2	Brugada Syndrome 06/2012 - 12/2007
1	Necrosis 01/2024
1	Glucose Intolerance 11/2023
1	Body Weight (Weight, Body) 11/2023
1	Morbid Obesity 12/2022
1	Pulmonary Edema 12/2022
1	Short Qt Syndrome 01/2020
1	Long Qt Syndrome 3 01/2020
1	Long Qt Syndrome 2 01/2020
1	Diabetic Angiopathies (Diabetic Angiopathy) 01/2020
1	Stroke (Strokes) 01/2020
1	Neoplasms (Cancer) 01/2020
1	Rupture 01/2020
1	Hypoxia (Hypoxemia) 01/2020
1	Coronary Artery Disease (Coronary Atherosclerosis) 01/2019

Drug/Important Bio-Agent (IBA)

33	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 12/2023 - 05/2003
21	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 01/2022 - 02/2002
17	CalciumIBA 01/2022 - 01/2002
14	Calcium-Calmodulin-Dependent Protein KinasesIBA 12/2021 - 12/2005
12	Proteins (Proteins, Gene)FDA Link 01/2020 - 05/2003
11	Adrenergic Agents (Adrenergic Drugs)IBA 01/2019 - 12/2005
6	Calmodulin (Calcium-Dependent Activator Protein)IBA 10/2021 - 01/2014
5	Phosphotransferases (Kinase)IBA 10/2021 - 06/2005
5	Protein Isoforms (Isoforms)IBA 01/2021 - 05/2003
5	SodiumIBA 06/2015 - 11/2003
5	Isoproterenol (Isoprenaline)FDA LinkGeneric 01/2012 - 02/2006
4	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2021 - 03/2011
4	phospholambanIBA 01/2019 - 02/2006
4	Adrenergic Receptors (Adrenergic Receptor)IBA 03/2016 - 05/2012
3	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2024 - 01/2019
3	Mitochondrial Permeability Transition PoreIBA 01/2024 - 01/2019
3	Islet Amyloid PolypeptideIBA 01/2020 - 02/2012
3	Peptides (Polypeptides)IBA 01/2019 - 02/2006
3	Ion Channels (Ion Channel)IBA 06/2015 - 06/2009
3	Adenosine Triphosphatases (ATPase)IBA 01/2014 - 10/2003
3	Endothelin-1 (Endothelin 1)IBA 09/2011 - 03/2006
2	Fatty Acids (Saturated Fatty Acids)IBA 11/2023 - 11/2018
2	Oxidoreductases (Dehydrogenase)IBA 11/2023 - 10/2021
2	Protein Kinases (Protein Kinase)IBA 10/2022 - 05/2015
2	Histone Deacetylases (Histone Deacetylase)IBA 01/2021 - 03/2008
2	E 4031IBA 01/2020 - 04/2011
2	Amyloid (Amyloid Fibrils)IBA 01/2020 - 02/2012
2	Transcription Factors (Transcription Factor)IBA 01/2020 - 06/2010
2	Adenosine Triphosphate (ATP)IBA 01/2019 - 03/2014
2	LipopolysaccharidesIBA 01/2017 - 01/2015
2	KN 93IBA 03/2016 - 02/2006
2	Ranolazine FDA Link 09/2013 - 04/2011
2	CalcineurinIBA 01/2012 - 09/2010
2	Caffeine (No Doz)FDA LinkGeneric 12/2010 - 09/2004
1	Malonyl Coenzyme A (Malonyl CoA)IBA 11/2023
1	Pyruvic Acid (Pyruvate)IBA 11/2023
1	Coenzyme A (CoA)IBA 11/2023
1	Brain Natriuretic Peptide (Natrecor)FDA Link 12/2022
1	AldosteroneIBA 12/2022
1	Glucose (Dextrose)FDA LinkGeneric 12/2022
1	Potassium Channels (Potassium Channel)IBA 10/2022
1	empagliflozinIBA 01/2022
1	RE1-silencing transcription factorIBA 01/2022
1	Serine (L-Serine)FDA Link 01/2021
1	PK 11195 (PK11195)IBA 01/2021
1	Inositol (Myoinositol)IBA 01/2021
1	JNK Mitogen-Activated Protein KinasesIBA 01/2021
1	6- (4- (trifluoromethoxy)phenyl)- 3- (trifluoromethyl)(1,2,4)triazolo(4,3- a)pyridineIBA 01/2020
1	toxin II (Anemonia sulcata)IBA 01/2020
1	Messenger RNA (mRNA)IBA 01/2020
1	AcetylglucosamineIBA 01/2020
1	Ketone BodiesIBA 01/2019
1	Mitochondrial Proton-Translocating ATPases (Mitochondrial ATP Synthase)IBA 01/2019
1	Cyclophilins (Cyclophilin)IBA 01/2019

Therapy/Procedure

8	Therapeutics 12/2022 - 03/2015